Study shows an oxime resin can be reused across many solid-phase peptide synthesis cycles to cut waste

Summary. Researchers at Université Laval in Canada reported in ACS Omega, published online on 17 October, a systematic study of reusing the Kaiser-DeGrado oxime resin as a greener approach to solid-phase peptide synthesis (SPPS). Solid-phase peptide synthesis builds peptides on an insoluble polymer support but consumes large volumes of reagents and solvents, and supports are usually discarded after a single assembly. The group tested how reproducibly the polystyrene-based oxime resin could be recovered and reused, assembling both linear and cyclic model peptides with different structural features.

Research context (RUO). The authors report that the oxime resin could be reused over multiple synthesis cycles without special treatment, still giving crude peptides in good purity and yield even after eight cycles, and that a regeneration step restored performance close to that of freshly prepared resin. They also show that the same resin can be reused several times within a single reaction vessel while using markedly fewer reagents and solvents, reducing material consumption and waste and simplifying the workflow. The paper is a synthetic-methods study focused on sustainability, with no biological testing. For peptide-chemistry laboratories, it offers a practical route to lower the solvent and material footprint of routine solid-phase synthesis.